SLAM (CDw150) 是麻疹病毒的细胞受体
1Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Nature
|September 6, 2000
概括
麻疹病毒是儿童死亡的主要原因,主要通过信号淋巴细胞激活分子 (SLAM) 感染细胞. 这一发现解释了麻疹的发病和免疫抑制,为研究提供了新的途径.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 麻疹病毒导致儿童死亡率很高,主要是由于严重免疫抑制导致的二次感染.
- 虽然一些麻疹病毒菌株使用CD46作为受体,但大多数临床分离物不使用CD46,表明存在其他细胞受体.
研究的目的:
- 为了识别麻疹病毒临床分离物使用的细胞受体.
- 阐明麻疹病毒进入和发病的机制,特别是免疫抑制.
主要方法:
- 非敏感细胞系与人类SLAM补充DNA的感染.
- 评估转染细胞中麻疹病毒结合,复制和细胞病变效应.
- 在各种细胞系中,将SLAM表达模式与麻疹病毒易感性相关联.
主要成果:
- 人类SLAM (信号淋巴细胞激活分子),也称为CDw150,作为麻疹病毒的细胞受体,包括埃德蒙斯顿菌株.
- 通过SLAM转移的细胞显示出麻疹病毒结合,复制和细胞病变效应.
- SLAM的细胞分布与细胞系对临床麻疹病毒分离物的敏感性相关.
结论:
- SLAM是麻疹病毒的关键细胞受体,解释了它的热带性和病原性.
- 识别SLAM为麻疹诱导的免疫抑制提供了关键的见解,并为治疗策略开辟了道路.
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