牙周病和冠状动脉心脏病风险
P P Hujoel1, M Drangsholt, C Spiekerman
1Department of Dental Public Health Sciences, School of Dentistry, Box 357475, University of Washington, Seattle, WA 98195, USA.
JAMA
|September 16, 2000
概括
这项研究发现没有令人信服的证据表明牙周病与冠状动脉疾病 (CHD) 风险有关. 需要进一步的研究来澄清牙健康和心脏病之间的关联.
科学领域:
- 心血管健康 心血管健康
- 口腔健康 口腔健康
- 流行病学 流行病学
背景情况:
- 以前的研究表明牙周病与冠状动脉心脏病 (CHD) 之间存在联系.
- 然而,由于潜在的混因素,现有的数据是不确定的.
- 这项研究旨在澄清牙周病和心血管疾病风险之间的关联.
研究的目的:
- 评估患有牙周炎,牙周炎或没有牙周疾病的人患冠状动脉心脏病 (CHD) 的风险.
- 调查牙周状况与心血管事件之间的关联.
主要方法:
- 一项前性队列研究,利用了第一项国家健康和营养检查调查流行病学后续研究 (1982-1992) 的数据.
- 包括8032名25-74岁的成年人,以前没有心血管疾病.
- 评估牙周状况 (牙周炎,牙炎,健康) 和追踪心血管疾病事件 (死亡,住院,再血管化).
主要成果:
- 在随访期间,1265人经历了心血管疾病事件.
- 经过风险因素调整后,牙炎与心脏病风险没有显著关联 (HR,1.05;95% CI,0.88-1.26).
- 牙周炎与心血管疾病事件的非显著增加风险相关 (HR,1.14;95% CI,0.96-1.36).
结论:
- 该研究没有找到令人信服的证据来确定牙周病与冠状动脉心脏病风险之间的因果关系.
- 牙疾病和心脏健康之间的关系需要进一步调查.
- 结果表明,混因素可能在观察到的关联中发挥重要作用.
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