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相关概念视频

Organization of Genes02:07

Organization of Genes

Overview
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Organization of Genes02:07

Organization of Genes

Overview
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...

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相关实验视频

Updated: Jul 5, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

基因组学是发生的事情.

V J DiRita1

  • 1Department of Microbiology and Immunology and Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Science (New York, N.Y.)
|September 19, 2000
PubMed
概括

霍乱是一种由Vibrio cholerae引起的严重腹疾病,几个世纪以来一直困扰着人类. 基因组测序现在正在揭示这种危险的微生物如何引起疾病的新见解.

科学领域:

  • 微生物学 微生物学
  • 基因组学就是基因组学.
  • 传染性疾病 传染性疾病

背景情况:

  • 霍乱仍然是一个重大的全球健康威胁,历史上造成广泛的流行病.
  • 致病剂Vibrio cholerae是一种水生细菌,可以感染人类.
  • 了解它的发病因子对于制定有效的控制策略至关重要.

研究的目的:

  • 探索了解Vibrio cholerae病原体的近期进展.
  • 突出基因组测序在揭示新见解中的作用.

主要方法:

  • 霍乱病毒病毒的基因组测序.
  • 对病原体与宿主相互作用的分析.

主要成果:

  • 基因组数据正在为Vibrio cholerae引起疾病的机制提供新的视角.
  • 微生物病原学的新方面正在被揭露.

结论:

  • 基因组洞察力正在彻底改变我们对霍乱的理解.
  • 对Vibrio cholerae基因组学的持续研究将加强疾病控制工作.

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相关实验视频

Last Updated: Jul 5, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM
06:30

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM

Published on: March 2, 2017

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018