在健康的男性中,定期的有氧运动可以预防和恢复与年龄相关的内皮依赖血管扩张的衰退
C A DeSouza1, L F Shapiro, C M Clevenger
1Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309, USA. desouzac@stripe.colorado.edu
定期的有氧运动可以防止与年龄相关的血管功能下降. 它还恢复了以前久坐不动的老年人健康的血管功能,降低了心血管疾病的风险.
科学领域:
- 心血管生理学心血管生理学
- 运动科学 运动科学
- 衰老研究研究 衰老研究
背景情况:
- 在久坐的人群中,内皮依赖的血管扩张随着年龄的增长而下降,从而增加心血管疾病的风险.
- 耐力训练的成年人表现出较低的与年龄有关的心血管风险.
- 研究了定期有氧运动对与年龄相关的血管扩张下降的影响.
研究的目的:
- 确定定期有氧运动如何影响与年龄相关的内皮依赖血管扩张的衰退.
- 评估有氧运动是否可以逆转老年久坐的男性受损的血管扩张.
主要方法:
- 横截面研究比较年轻 (22-35岁) 和老年 (50-76岁) 久坐和耐力训练的男性.
- 在动脉内注射乙胆和酸的过程中,使用压力计整体图测量前臂血流 (FBF).
- 对于以前久坐不动的老年男性,进行为期3个月的有氧运动干预 (步行).
主要成果:
- 久坐不动的老年男性显示,与年轻的久坐不动男性相比,乙胆介导的FBF反应降低了25%.
- 在耐力训练的男性中,没有观察到乙胆介导的FBF与年龄相关的差异.
- 在以前久坐不动的老年男性中,3个月的有氧运动干预增加了约30%的血管扩张,达到年轻成年人所见的水平.
结论:
- 定期的有氧运动有效地防止与年龄相关的内皮依赖血管扩张的丧失.
- 有氧运动可以恢复以前久坐不动的老年人的正常血管扩张.
- 血管功能的这种改善可能是降低心血管疾病风险的关键机制.
更多相关视频
09:04Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy
Published on: February 20, 2018
08:35Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
Published on: August 17, 2022
相关概念视频
Respiration and Gaseous Exchange
Respiration involves the exchange of gases, especially oxygen (O2) and carbon dioxide (CO2), between the alveoli and body cells, a process facilitated by blood circulation. As a result, the cardiovascular system, which involves the...
The Effect of Aging on Tissues
Exercise and Cardiac Output
Sustained exercise increases the muscles' oxygen demand, which can be met...
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...
Coronary Artery Disease IV: Preventive Measures
