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相关概念视频

Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Specialized Characteristics of Cardiac Muscles01:27

Specialized Characteristics of Cardiac Muscles

The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy reserves in...
Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...

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相关实验视频

Updated: Jul 8, 2026

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

对于心脏发育的遗传蓝图.

D Srivastava1, E N Olson

  • 1Department of Molecular Biology, University of Texas, Southwestern Medical Center at Dallas, 75390-9148, USA. dsriva@mednet.swmed.edu

Nature
|September 23, 2000
PubMed
概括
此摘要是机器生成的。

遗传突变是儿童先天性心脏病的主要原因,导致严重的心脏形. 了解这些遗传因素对于治疗心脏缺陷和通过细胞重编程探索心脏修复至关重要.

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Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution
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Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution

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Analysis of Cardiac Chamber Development During Mouse Embryogenesis Using Whole Mount Epifluorescence

Published on: April 17, 2019

相关实验视频

Last Updated: Jul 8, 2026

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution
07:30

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution

Published on: October 7, 2016

Analysis of Cardiac Chamber Development During Mouse Embryogenesis Using Whole Mount Epifluorescence
06:27

Analysis of Cardiac Chamber Development During Mouse Embryogenesis Using Whole Mount Epifluorescence

Published on: April 17, 2019

科学领域:

  • 心血管遗传学 心血管遗传学
  • 发展生物学 发展生物学
  • 儿童心脏病学 儿童心脏病学

背景情况:

  • 先天性心脏病 (CHD) 是儿童群体中主要的非传染性死亡原因.
  • 以前被认为是多因素的,许多心脏异常现在与发育控制基因的特定突变有关.
  • 遗传突变可以导致出生时严重的心脏形或在以后的生活中出现更微妙的问题.

研究的目的:

  • 为了阐明先天性心脏病的遗传基础.
  • 探索发育控制基因在心脏形中的作用.
  • 调查心脏修复策略中遗传重编程的潜力.

主要方法:

  • 关于遗传突变和心脏发育的当前文献的综述.
  • 分析与先天性心脏缺陷相关的遗传数据.
  • 探索用于心脏再生的基因编辑和细胞重编程技术.

主要成果:

  • 关键发育控制基因的突变直接涉及到CHD病例的很大一部分.
  • 遗传基础解释了一系列心脏异常,从严重的形到微妙的缺陷.
  • 了解这些遗传通路为新的治疗方法开辟了道路.

结论:

  • 遗传突变是先天性心脏病病因子学的关键因素.
  • 准发育性基因通路为新型治疗和再生医学提供了潜力.
  • 对基因重编程的进一步研究可能会彻底改变儿科心脏护理.