在服用口服避孕药的年轻女性中,交感活动和巴罗反射敏感性
C T Minson1, J R Halliwill, T M Young
1Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA. minson.christopher@mayo.edu
口服避孕药 (OC) 的使用会改变巴罗反射敏感度. 与OC使用高激素阶段相比,在低激素阶段,交感和心血管巴罗反射灵敏度都更高.
科学领域:
- 心血管生理学心血管生理学
- 神经内分泌学神经内分泌学
背景情况:
- 口服避孕药 (OCs) 被广泛使用,它们的荷尔蒙波动可能会影响心血管调节.
- 了解OCs对自主神经系统的影响对于妇女健康至关重要.
研究的目的:
- 调查在口服避孕药使用的不同阶段对交感和心血管巴罗反射灵敏度的变化.
- 为了比较OC使用期间的巴罗反射灵敏度变化与自然月经周期的变化.
主要方法:
- 评估了使用酸和烯挑战的交感巴罗反射灵敏度,测量了肌肉交感神经活动和血压.
- 通过分析R-R间隔和缩血压之间的关系来确定心血管巴罗反射灵敏度.
- 在口服避孕周期的低激素 (安慰剂) 和高激素阶段评估了9名女性.
主要成果:
- 在休息肌肉交感神经活动或不同阶段血中诺亚上腺素水平之间没有发现显著差异.
- 与高激素阶段相比,在低激素阶段,交感巴罗反射灵敏度和平均动脉压显著更高.
- 在低激素阶段,心血管巴洛反射灵敏度也明显大于在高激素阶段.
结论:
- 交感和心血管巴罗反射敏感性在28天口服避孕药周期内呈现动态变化.
- 在使用口服避孕药时,巴罗反射灵敏度的这些变化与在自然月经周期中观察到的不同.
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