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Updated: May 7, 2026

Recombinant Retroviral Production and Infection of B Cells
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Recombinant Retroviral Production and Infection of B Cells

Published on: February 19, 2011

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类开关重组和高突变需要激活诱导的cytidine deaminase (AID),一种潜在的RNA编辑酶

M Muramatsu1, K Kinoshita, S Fagarasan

  • 1Department of Medical Chemistry, Graduate School of Medicine, Institute for Virus Research, Kyoto University, Japan.

Cell
|September 28, 2000
PubMed
概括

这项研究揭示了激活诱导的cytidine deaminase (AID) 对B细胞类切换和体质突变至关重要. 在小鼠中AID缺乏导致这些过程的完全失败,影响抗体多样性.

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