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脂蛋白脂酶活性与胸痛的严重程度有关. 在Regress研究小组的研究中

J J Kastelein¹, J W Jukema, A H Zwinderman

¹Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

|October 4, 2000

概括

脂蛋白脂酶 (LPL) 的活性和质量与心血管疾病的严重程度有关. 较低的LPL水平与心痛和缺血的增加相关,这表明LPL影响冠状动脉疾病的风险.

科学领域:

心血管科学心血管科学
脂质代谢脂质代谢是什么
酶学是一种酶学.

背景情况:

高水平的富含甘油三脂脂蛋白是心血管疾病的重要危险因素.
脂蛋白脂酶 (LPL) 活性对于清除这些脂蛋白至关重要,可能调节心血管风险.

研究的目的:

研究LPL活动和质量以及男性冠状动脉疾病患者缺血症的严重程度之间的关系.
评估LPL水平与缺血的临床指标之间的关联,如胸痛和静音缺血.

主要方法:

来自REGRESS试验的男性冠状动脉疾病患者队列中的测量后肝素LPL活性和质量.
通过24小时的门诊心电图监测,使用NYHA分类和静音缺血来评估心痛的严重程度.
分析了LPL水平,心痛类和缺血负担之间的相关性.

主要成果:

较低LPL活动四分位数的患者报告了更严重的胸痛 (47%的III/IV类vs.最高四分位数的29%,P=0.002).
较低的LPL活动四分位数在心电图监测上表现出较高的缺血总负担 (36.5+/-104.1 mm x min与14.8+/-38.8 mm x min相比,P=0.001).
在LPL活动和质量 (r=0.70,P<0.0001) 之间发现了强烈的相关性;与NYHA类相关的LPL质量 (P=0.012).

结论:

在LPL质量/活性和缺血症严重程度 (心血管炎类,心电图) 之间存在显著的关系.
慢性肺炎似乎通过催化和非催化机制影响冠状动脉疾病的风险.

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