GH释放激素和GH释放-6用于GH缺乏的成年人的诊断测试
1Institute of Endocrinology, University Clinical Centre, Belgrade, Yugoslavia.
Lancet (London, England)
|October 13, 2000
概括
联合GH释放激素 (GHRH) 加GH释放-6 (GHRP-6) 测试是诊断成人生长激素 (GH) 缺乏症的安全可靠方法. 这种测试比胰岛素耐受性测试 (ITT) 具有更好的可重复性.
科学领域:
- 内分泌学 在内分泌学.
- 诊断测试 诊断测试 诊断测试 诊断测试 诊断测试
- 荷尔蒙缺乏症 荷尔蒙缺乏症
背景情况:
- 成人生长激素 (GH) 缺乏症的诊断依赖于挑性测试.
- 胰岛素耐受性测试 (ITT) 是受欢迎的,但其可复制性和不便性较差.
- 联合GH释放激素 (GHRH) 和GH释放-6 (GHRP-6) 测试是一种强大的GH分泌刺激剂.
研究的目的:
- 为了比较来自GHRH/GHRP-6测试的GHH峰值与ITT.
- 评估GHRH/GHRP-6测试在健康对照组和缺乏GH的成年人中的可靠性.
- 通过GHRH/GHRP-6测试,确定成人GH缺乏症的诊断标准.
主要方法:
- 一项多中心研究,涉及125名患有下垂体疾病的成年患者和125名健康对照.
- 静脉注射GHRH (1μg/kg) 加上GHRP-6 (1μg/kg) 的使用.
- 在120分钟内测量GH峰值;在27个对照组和所有病例中进行了ITT.
主要成果:
- GHRH/GHRP-6测试没有显示任何副作用,并且不受临床因素的影响.
- 平均GH峰值在对照组 (59.2μg/L) 显著高于用GHRH/GHRP-6治疗的病例 (4.1μg/L).
- 接收器运行特性 (ROC) 曲线分析显示出良好的性能,表明正常的切断值为≥20.00μg/L,不足的切断值为≤10.00μg/L.
结论:
- GHRH/GHRP-6测试是一种方便,安全和可靠的成年GH缺乏症诊断工具.
- 这种测试不会受到可能改变GH分泌模式的因素的影响.
- 引起的GH度≥15.0μg/L可以准确地区分健康和GH缺乏的成年人.
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