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Updated: Jun 4, 2026

Ex vivo Culturing of Whole, Developing Drosophila Brains
08:39

Ex vivo Culturing of Whole, Developing Drosophila Brains

Published on: July 27, 2012

齐布洛洛特调节了Drosophila大脑转型期间的actin组装

I Boquet1, R Boujemaa, M F Carlier

  • 1Laboratoire Développement, Evolution, et Plasticité du Système Nerveux, Institut de Neurobiologie Alfred Fessard, CNRS, Gif-sur-Yvette, France.

Cell
|October 13, 2000
PubMed
概括

研究人员确定了Ciboulot (Cib),这是一种新型蛋白质,在Drosophila大脑转型过程中对轴突生长至关重要. 西布的作用与profilin相似,它与 (Chickadee) 合作,调节动力学,以确保正常发育.

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Generation of Straight or Branched Actin Filaments

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Arp2/3 Complex
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Formation of Higher-order Actin Filaments

The polymerization of G-actin monomers into filamentous F-actin is a multi-step process. Once the F-actins are formed, they can bundle together in different arrangements to form higher-order networks and regulate cellular functions. Common examples include the formation of lamellipodia and filopodia at the cell's leading edge by actin reorganization in a migrating cell. The microvilli on the brush border epithelial cells are also formed through the F-actin network.
The high-order actin networks...
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Mechanism of Filopodia Formation

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Mechanism of Lamellipodia Formation

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Cell Motility through Blebbing

Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
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Cytoskeletal Coordination in Cell Migration

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