Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Risk factors and efficacy of different intravitreal treatment options for symptomatic focal vitreomacular traction with or without full-thickness macular hole.

International ophthalmology·2025
Same author

Co-delivery of HIV pre-exposure prophylaxis (PrEP) and HIV testing among publicly insured adolescents and young adults (AYA) receiving medication for opioid use disorder (MOUD).

Drug and alcohol dependence·2024
Same author

Conditional expression of Ki-Ras<sup>G12V</sup> in the mammary epithelium of transgenic mice induces estrogen receptor alpha (ERα)-positive adenocarcinoma.

Oncogene·2017
Same author

Altered composition of epidermal lipids correlates with Staphylococcus aureus colonization status in atopic dermatitis.

The British journal of dermatology·2017
Same author

A new murine model of sustainable and durable chronic critical limb ischemia fairly mimicking human pathology.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2015
Same author

Are there adverse consequences of quizzing during informed consent for HIV research?

Journal of medical ethics·2011

相关实验视频

Updated: Jun 26, 2026

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

在小鼠表皮中由暂时控制的RXRalpha突变产生的皮肤异常.

M Li1, A K Indra, X Warot

  • 1Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch.

Nature
|October 18, 2000
PubMed
概括

视网膜X受体α (RXRalpha) 对于皮肤平衡至关重要. 在成年小鼠中选择性切除RXRalpha揭示了它在毛发循环,角质细胞增殖和分化中的重要作用.

科学领域:

  • 皮肤病学 皮肤病学
  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 像RAR和VDR这样的核受体与表皮发育和恒温有关.
  • 这些受体通常与RXR异构,以调节基因转录.
  • 之前对皮肤RXRs的遗传研究受到致死性和性效应的限制.

研究的目的:

  • 为了克服研究RXRalpha在皮肤中的功能的局限性.
  • 为了研究RXRalpha在成年老鼠表皮中的特定作用.
  • 阐明RXRalpha在皮肤平衡和疾病中的机制.

主要方法:

  • 在小鼠中开发一种用于空间时间控制体质突变的新技术.
  • 用于选择性切除RXRalpha的使用的他莫西芬诱导的Cre-ER(T) 重组酶.
  • 针对性RXRalpha淘汰在成年小鼠角质细胞中.

主要成果:

  • RXRalpha 在调节头发循环中起着至关重要的作用.
  • RXRalpha对于表皮角质细胞的增殖至关重要.
  • RXRalpha对于角质细胞的分化至关重要,可能是通过RXR/VDR异构体.

更多相关视频

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

相关实验视频

Last Updated: Jun 26, 2026

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

结论:

  • 在成年哺乳动物中,RXRalpha是维持皮肤平衡不可或缺的.
  • 有针对性的基因操纵为研究皮肤生物学中必不可少的基因提供了强大的工具.
  • 了解RXRalpha的功能为皮肤疾病提供了潜在的治疗点.