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Updated: Jun 25, 2026

07:36
Angiogenesis in the Ischemic Rat Lung
Published on: February 8, 2013
在急性肺损伤中,肺毛细血管内皮结合的血管酶转化酶活性
S E Orfanos1, A Armaganidis, C Glynos
1Critical Care Department, Evangelismos Hospital, University of Athens Medical School, Greece. stelmar@ath.forthnet.gr
Circulation
|October 18, 2000
概括
在急性肺损伤 (ALI) 中,肺毛细血管内皮结合的血管酶转化催化酶 (ACE) 活性下降. 这种减少是肺损伤严重程度和内皮功能障碍的敏感标记.
科学领域:
- 肺部医学 肺部医学
- 关键护理医学 关键护理医学
- 生物化学 生物化学
背景情况:
- 肺毛细血管内皮结合的血管酶转化催化酶 (PCEB-ACE) 活性是动物模型中肺损伤的敏感指标.
- 在人类中,PCEB-ACE活性的改变可能表明急性肺损伤 (ALI).
- PCEB-ACE活性可以作为肺毛细血管内皮功能障碍的可量化的标志物.
研究的目的:
- 为了研究ALI患者的PCEB-ACE活性变化.
- 为了确定PCEB-ACE活性是否与肺损伤严重程度相关.
- 评估PCEB-ACE活性作为肺毛细血管内皮功能障碍的可量化的标志物.
主要方法:
- 使用指标稀释技术来测量合成ACE基质 (3H-二-Phe-Ala-Pro) 的肺过水解.
- 在33名机械通风,危急病患者中进行了测量,患者的肺损伤分数 (LIS) 不同.
- 计算了动力参数,包括Amax/Km,并与临床得分 (APACHE II,LIS) 和心脏输出 (CO) 相关联.
主要成果:
- 在ALI连续的早期,PCEB-ACE活性,表示为A (max) /K (m),下降.
- 降低的ACE活性与APACHE II分数和LIS相反相关.
- 随着心脏输出量的增加,水解量下降,在CO和A (max) /K (m) 之间观察到不同的模式.
结论:
- 在急性肺损伤的早期,PCEB-ACE活性会下降.
- PCEB-ACE活性下降与ALI和潜在疾病的临床严重程度相关.
- PCEB-ACE活性是ALI患者肺毛细血管内皮功能障碍的潜在可量化的标志物.
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