严重的生活事件和先天性形:一项全国性研究,包括完整的随访
1Neuropediatric Department, John F Kennedy Institute, Glostrup, Denmark. dhansen@dadlnet.dk
Lancet (London, England)
|October 19, 2000
概括
怀孕期间的严重情绪压力,特别是孩子的死亡,与先天性形的风险增加有关,特别是神经顶缺陷. 这项研究证实了心理社会压力与出生缺陷之间的重要联系.
科学领域:
- 生殖医学 生殖医学
- 发育生物学 发展生物学
- 精神病体医学是一种精神病体医学.
背景情况:
- 理论上,在关键发育时期的情绪压力,如器官生成,有助于先天性形.
- 这项研究探讨了心理社会压力提高出生缺陷的发生率的假设,特别关注头骨神经的缺陷.
研究的目的:
- 测试假设,怀孕期间经历的严重生活事件会增加先天性形的患病率.
- 确定心理社会压力,特别是与儿童死亡有关的压力,是否与神经形形的风险增加有关.
主要方法:
- 一项后续研究使用国家登记册确定了在1980-1992年间接触过严重生命事件 (伴侣/孩子死亡,癌症,心肌梗塞) 的孕妇.
- 对3560个暴露妊娠的队列进行了比较,与20299个随机选择的未暴露妊娠进行了比较.
- 严重生命事件被定义为伴侣或孩子的死亡或第一次癌症/心肌梗塞住院.
主要成果:
- 与对照组相比,在暴露于严重生命事件 (1.18%) 的怀孕中观察到神经形形的频率更高 (0.65%),调整后的几率比率为1.54.
- 在连续两次怀孕中暴露的妇女显示,神经形形的风险较高 (OR 2.99).
- 在头三个月内老孩子的死亡与头骨神经的形严重相关 (OR 4.75),儿童意外死亡对头骨神经 (OR 8.36) 和其他形 (OR 3.64) 的几率比率甚至更高.
结论:
- 研究结果支持怀孕期间严重的情绪压力可能导致先天性形的假设.
- 该研究强调了神经对压力诱导的发育异常的特别脆弱性.
- 怀孕早期儿童的死亡成为特定类型的出生缺陷的重要风险因素.
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