CD95/CD95连接体对表皮细胞的相互作用在宿主防御中的Pseudomonas aeruginosa
H Grassmé1, S Kirschnek, J Riethmueller
1Department of Physiology, University of Tuebingen, Gmelinstrasse 5, 72076 Tuebingen, Germany.
Science (New York, N.Y.)
|October 20, 2000
概括
伪菌的肺部感染通过CD95/CD95连接物通路触发细胞死亡. 阻止这个系统保护肺细胞,并防止小鼠的败血症,突出其在感染中的关键作用.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 微生物学 微生物学
背景情况:
- 伪菌 (Pseudomonas aeruginosa) 是一个重要的病原体,导致严重的,危及生命的肺部感染.
- 肺上皮细胞对于呼吸系统的健康和对病原体的防御至关重要.
研究的目的:
- 研究CD95/CD95连接体系统在Pseudomonas aeruginosa诱导的肺上皮细胞亡中的作用.
- 确定在P. aeruginosa感染期间CD95/CD95连接物缺乏对肺上皮细胞的体内和体外影响.
主要方法:
- 鼠标和肺上皮细胞感染了Pseudomonas aeruginosa.
- 使用CD95和CD95连接体缺陷模型对亡的评估.
- 在体内对败血症发展的评估.
主要成果:
- 感染P. aeruginosa会激活肺上皮细胞中的内源性CD95/CD95连接体系统,从而诱导细胞亡.
- 在体外和体外模型中,上皮细胞上CD95或CD95连接体的缺陷显著降低了细胞亡.
- 与正常小鼠不同的是,CD95或CD95连接体缺乏的小鼠在P. aeruginosa感染后迅速发生败血症.
结论:
- CD95/CD95连接体系统在P. aeruginosa诱导的肺上皮细胞亡中起着至关重要的作用.
- 准CD95/CD95连接物通路可能是缓解严重P. aeruginosa肺部感染和预防败血症的治疗策略.
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