从银行到诊所,使用基于亡的治疗剂
1Merck Frosst Centre for Therapeutic Research, Merck Research Laboratories, Pointe Claire-Dorval, Quebec, Canada. donald_nicholson@merck.com
Nature
|October 26, 2000
概括
细胞亡,编程细胞死亡,是人类疾病的基础. 调节亡提供了令人兴奋的治疗潜力,预计很快就会在临床上进行治疗.
科学领域:
- 生物医学科学 生物医学科学
- 细胞生物学 细胞生物学
- 病变发生学研究 病变发生学研究
背景情况:
- 细胞亡,或编程细胞死亡,是许多人类疾病的发病的一个关键因素.
- 了解亡是开发新型治疗策略的关键.
- 尽管面临挑战,但细胞死亡途径的调节提供了显著的治疗机会.
研究的目的:
- 审查亡在人类疾病发病过程中的作用.
- 探索调节亡的治疗潜力.
- 评估细胞亡调节疗法的临床应用时间表.
主要方法:
- 疾病病原发生的回顾性分析.
- 审查当前的亡研究.
- 评估治疗开发的挑战和前景.
主要成果:
- 亡过程始终与人类疾病的进展有关.
- 通过向细胞亡,产生了重要的治疗机会.
- 虽然存在挑战,但临床应用预计将在几年内实现.
结论:
- 亡在人类疾病中起着核心作用.
- 向细胞亡提供了有前途的治疗途径.
- 预计在不久的将来,亡调节疗法的临床转化将在不久的将来出现.
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