橄醇氧醇可以防止被动吸烟引起的氧化应激
F Visioli1, C Galli, E Plasmati
1University of Milan, Institute of Pharmacological Sciences, Milan, Italy. francesco.visioli@unimi.it
Circulation
|November 1, 2000
概括
橄厂废水提取物富含氧醇,被测试其对氧化应激的保护作用. 提取物显著降低了暴露于被动吸烟的老鼠中氧化损伤的标志物.
科学领域:
- 生物化学 生物化学
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 氧化应激与退行性疾病有关.
- 在地中海饮食中常见的饮食抗氧化剂提供了保护.
- 橄厂废水 (OMWW) 含有丰富的性抗氧化剂,如氧化.
研究的目的:
- 为了研究低剂量OMWW提取物对大鼠侧流烟引起的氧化应激的影响.
- 为了评估8-异质前列腺素F ((2alpha) 作为氧化应激的生物标志物的尿液分泌.
主要方法:
- 大鼠每天服用OMWW提取物 (5毫克/公斤) 剂量,持续4天.
- 动物每天暴露在侧流烟雾中20分钟.
- 尿中的8-异质前列腺素F ((2α) 排泄被测量为脂质过氧化的指标.
主要成果:
- 被动吸烟增加了尿路8-异质前列腺素F ((2α) 的排泄,在48小时后增加了44%,在96小时后增加了55%.
- 在48小时内,OMWW提取物治疗完全阻止了这种增加.
- 提取物导致96小时后8-异质前列腺素F ((2α)) 排泄的增加较小 (34%对55%).
结论:
- 来自OMWW的低剂量酸醇有效地减少了小鼠侧流烟雾诱导的氧化应激的后果.
- OMWW 提取物显示出作为一种保护剂,防止环境氧化损害的潜力.
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