冠状动脉组合和巨细胞透在从糖尿病患者的atherctomy标本
P R Moreno1, A M Murcia, I F Palacios
1Gill Heart Institute, University of Kentucky, Lexington, KY, USA. pmoreno@pop.uky.edu
Circulation
|November 1, 2000
概括
糖尿病患者在冠状动脉病变中具有更多的脂质丰富的斑块和巨细胞透,增加了血栓形成的风险. 治疗类型没有改变这些发现.
科学领域:
- 心血管病理学心血管病理学
- 糖尿病学 糖尿病学
- 动脉样硬化的研究研究.
背景情况:
- 富含脂质,炎症性动脉样硬化病变增加了糖尿病中斑块破裂的风险.
- 斑块破裂和血栓形成是糖尿病患者死亡的主要原因.
- 在冠状动脉病变中量化脂质组成和巨细胞透对于了解糖尿病动脉样硬化至关重要.
研究的目的:
- 量化和比较患有糖尿病和没有糖尿病的患者冠状动脉病变中的脂质组成和巨细胞透.
- 评估糖尿病,斑块特征和血栓形成之间的关联.
- 调查糖尿病治疗是否影响斑块组成和血栓形成风险.
主要方法:
- 分析了来自糖尿病患者的47个冠状动脉切除术样本和来自非糖尿病患者的48个样本.
- 三色染色用于斑块组成和免疫染色用于巨细胞透.
- 临床和人口统计数据,斑块脂质含量,巨细胞透和血栓发病率在不同组之间的比较.
主要成果:
- 糖尿病患者在冠状动脉病变中显示出含脂丰富的动脉动脉瘤 (7%与2%) 和巨细胞 (22%与12%) 的百分比明显更高.
- 血栓发生率在糖尿病患者中较高 (62%对40%).
- 不同糖尿病治疗组 (胰岛素,硫尿素,饮食) 之间没有观察到斑块组成,巨细胞透或血栓的显著差异.
结论:
- 糖尿病患者的冠状动脉组织表现出更大的脂质丰富的动脉动脉瘤和巨细胞透,导致血栓形成的增加.
- 这些发现表明,糖尿病患者对冠状动脉血栓形成的脆弱性增加.
- 糖尿病治疗方式似乎没有影响这些特定的病理特征.
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