用电子束计算断层扫描对冠状动脉微血管功能的最小侵入性评估
S Möhlenkamp1, L O Lerman, A Lerman
1Department of Physiology, Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, MN, USA.
Circulation
|November 9, 2000
概括
高胆固醇血症会损害心肌血流量和体积储备,特别是可招募的微循环. 电子束计算断层扫描 (EBCT) 可以评估这些微血管变化在条件,如高胆固醇血症.
科学领域:
- 心血管生理学心血管生理学
- 医学成像医学成像
- 微循环研究 微循环研究
背景情况:
- 电子束计算断层扫描 (EBCT) 指示器稀释方法估计心内血液体积 (BV) 和输液 (F).
- 关系BV=aF+b√F描述了可招募的 (a) 和不可招募的 (b) 微循环元件.
- 高胆固醇血症 (HC) 可能会改变微血管功能.
研究的目的:
- 将EBCT衍生的BV和F与基于多普勒超声波的冠状动脉血流 (CBF) 进行比较.
- 量化正常和HC猪对血管活性药物的微血管反应差异.
- 评估高胆固醇血症对心肌微循环的影响.
主要方法:
- 在14只HC和14只对照猪中进行了对比增强的EBCT研究.
- 测量BV,F和CBF在基线和腺和酸甘油输注后.
- 微血管储备和功能成分分布的分析.
主要成果:
- 腺素诱导的BV和CBF储量在HC猪中减弱 (P<0.03和P<0.01).
- 与对照组相比,HC猪的可招募性BV始终较低.
- 非可招募的BV储备在HC猪中也被减弱 (P<0.001),表明抵抗血管功能受损.
结论:
- 通过EBCT,可以对心脏内微循环功能进行最少的侵入性评估.
- 通过EBCT,可以评估微血管血液体积分布到功能成分.
- 这种方法对于评估冠状动脉微循环在诸如高胆固醇血症之类的病理生理状态是有价值的.
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