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Updated: Jun 25, 2026

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

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Published on: November 1, 2010

1994-1998年欧洲的艾滋病:欧洲艾滋病研究中心的研究报告

A Mocroft¹, C Katlama, A M Johnson

¹Royal Free Centre for HIV Medicine, Royal Free and University College London Medical School, UK.

Lancet (London, England)

|November 9, 2000

概括

高活性抗逆转录病毒治疗 (HAART) 在HIV-1患者中显著降低了艾滋病定义疾病 (ADIs) 的发生率. 接受HAART治疗的患者具有较低的ADI风险,即使CD4计数较低.

科学领域:

传染性疾病传染性疾病
免疫学免疫学免疫学
公共卫生公共卫生

背景情况:

针对HIV-1感染的高活性抗逆转录病毒治疗 (HAART) 的出现可能改变了艾滋病定义疾病 (ADIs) 的格局.
评估HAART对ADI发病率和特征的影响对于了解疾病进展和治疗疗效至关重要.

研究的目的:

评估HIV-1患者随着时间的推移对ADI发生率的变化.
分析HAART,CD4淋巴细胞计数和ADI发生之间的关系.
为了确定HAART引入后诊断的ADI类型的变化.

主要方法:

一项前性,观察性,多中心研究,涉及52家欧洲诊所的7300多名HIV-1患者.
根据CD4淋巴细胞计数和治疗状态分层的每100个患者年发生率的计算.
分析特定ADI的趋势,包括细胞巨乳病毒视网膜炎,Mycobacterium avium复合体和非霍奇金淋巴瘤.

主要成果:

在1994年至1998年期间,ADI的总体发病率从每100个患者年中的30.7个大幅下降至2.5个.
在ADI诊断时,CD4的中位数显著增加,表明免疫状态有所改善.
接受HAART治疗的患者在所有CD4层中始终表现出较低的ADI率.
由于细胞巨乳病毒视网膜炎和Mycobacterium avium复合物的ADI比例下降,而非霍奇金淋巴瘤增加,成为HAART治疗患者的主要ADI.

结论:

在HIV-1感染者中,HAART疗法明显降低了ADI的发病率.
随着时间的推移,ADI的风险有所降低,并且无论CD4计数如何,接受HAART的患者的风险更低.
对接受联合抗逆转录病毒治疗的患者进行持续的长期监测对于跟踪新出现的诊断至关重要.

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