用口服维生素K治疗与华法林相关的凝血病:一项随机对照试验
M A Crowther1, J Julian, D McCarty
1Department of Medicine, McMaster University, Hamilton, ON, Canada. crowthrm@fhs.csu.mcmaster.ca
Lancet (London, England)
|November 15, 2000
概括
低剂量口服维生素K有效降低高国际正常化比率 (INR) 在华法林患者. 这种治疗比安慰剂更安全,更有效,减少出血风险.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 华法林相关的凝血病是一种常见的临床问题.
- 过度抗凝血患者需要有效的管理策略.
- 国际规范化比率 (INR) 监测对于华法林治疗至关重要.
研究的目的:
- 评估维生素K在快速降低INR升高的安全性和有效性.
- 在接受华法林的患者中,将维生素K治疗与安慰剂进行比较.
主要方法:
- 进行了一项多中心,双盲,安慰剂控制,随机化试验.
- 具有INR4.5-10.0的患者接受1毫克口服维生素K或安慰剂.
- 主要结局是治疗后一天的INR;次要结局包括3个月的出血和血栓形成.
主要成果:
- 与安慰剂相比,维生素K显著加快了INR的降低 (56%对20%,p=0.001).
- 接受维生素K治疗的患者出现的出血次数较少 (4%对17%,p=0.050).
- 发生出血的几率比率偏好维生素K (OR 0.87,95% CI 0.019-0.999).
结论:
- 低剂量口服维生素K是一种安全有效的干预措施.
- 它提供了一种快速有效的手段来降低华法林患者的INR升高.
- 维生素K治疗可以降低出血并发症的风险.
相关概念视频
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