服用口服维生素B后改善血管内皮功能:通过降低度的自由血类固醇氨酸的作用
J C Chambers1, P M Ueland, O A Obeid
1National Heart and Lung Institute, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
Circulation
|November 15, 2000
概括
补充维生素B,包括叶酸和维生素B12,改善了冠心病 (CHD) 患者的血管内皮功能. 这种改善与较低的自由血homocysteine水平相关,表明心血管风险降低.
科学领域:
- 心血管医学 心血管医学
- 营养科学 营养科学
- 血管生物学 血管生物学
背景情况:
- 过高homocysteinemia是冠状动脉心脏病 (CHD) 的已知危险因素.
- 补充B族维生素可以降低血类固醇水平.
- 降低同氨酸对心脏病患者血管功能的影响尚不清楚.
研究的目的:
- 研究叶酸和维生素B12补充剂对患有心脏病的男性血管内皮功能的影响.
- 为了确定维生素B疗法是否会改变血类固醇度并改善流媒体扩张.
主要方法:
- 89名患有心血管疾病的男性每天接受叶酸 (5毫克) 和维生素B12 (1毫克) 或安慰剂,持续8周.
- 测量了手臂动脉流媒体扩张 (内皮依赖) 和甘氨酸诱导的扩张 (内皮独立).
- 血类型半氨酸,血清叶酸和维生素B12水平在基线和治疗后被评估.
主要成果:
- 维生素B治疗显著改善了流媒体扩张 (2.5%至4.0%,P=0.002),而安慰剂没有显示任何变化.
- 维生素治疗降低了总体,蛋白质结合和自由血类固醇水平.
- 改善的流媒体扩张与减少的自由血类固醇相关 (r=-0.26,P=0.001).
- 亚甘油诱导的扩张保持不变,表明内皮特异性影响.
结论:
- 叶酸和维生素B12补充剂可增强心血管疾病患者的血管内皮功能.
- 这种有益的效果很可能是由降低的自由血homocysteine度介导的.
- 通过补充B族维生素来降低同型半氨酸可能会降低心血管风险.
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