狄戈辛对急性心房引起的心房折射性变化的影响
C Sticherling1, H Oral, J Horrocks
1Division of Cardiology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109-0022, USA.
Circulation
|November 15, 2000
概括
在心房动 (AF) 发作后,迪戈辛会恶化心房折射性,增加复发AF的风险. 这种效应很可能是由于狄戈辛的作用.
科学领域:
- 心血管电生理学 心血管电生理学
- 心脏节律失常症 心脏节律失常症
- 药理学 药理学是指药理学的学科.
背景情况:
- 心房动 (AF) 缩短了心房有效耐火期 (ERP),增加了对进一步的AF发作的敏感性.
- 心房折射率的急性变化可能源于心跳动引起的细胞内过载.
研究的目的:
- 为了调查是否狄戈辛,一种增加细胞内的药物,增强了AF对人类心房折射率的急性影响.
主要方法:
- 在自主阻塞后测量了38名健康成年人的心房ERP,其中19名接受了狄戈辛治疗.
- 在短暂的AF发作之前和之后,在350和500毫秒的基本驱动周期长度 (BDCLs) 中评估了心房ERP.
- 在狄戈辛和对照组之间比较AF后ERP变化和二次AF发作的发生率.
主要成果:
- 与AF前值相比,AF后心房ERP在两组中都明显较短.
- 在这两种BDCL中,心房ERP的减少在狄戈辛组明显大于对照组.
- 二次性AF发作发生在迪戈辛组 (32%) 与对照组 (16%) 相比更频繁.
结论:
- 迪戈辛增加了AF发作后心房折射率的急性缩短.
- 这种由狄戈辛增强的药物使患者有机会重新诱导AF,而不依赖于vagotonic效应.
- 这些发现表明,狄戈辛对细胞内的作用有助于其在AF中的前节律失常潜力.
相关概念视频
Factors Influencing Heart Rate
The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Disturbances in Heart Rhythm
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Measurement of Blood Pressure
Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a stethoscope.
Mitral Regurgitation I: Introduction
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Introduction Cardiac Emergencies
Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
Pulmonary Embolism I: Introduction
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...


