氨酸增加了人体血管光滑肌肉细胞中的互乐金-6合成
Circulation
|November 15, 2000
概括
血清素 (5-基三胺;5-HT) 通过5-HT2A受体和蛋白激酶C在人体血管细胞中增加了互白素-6 (IL-6) 的产生,这表明5-HT可能在动脉样硬化中促进血管炎症.
科学领域:
- 血管生物学 血管生物学
- 炎症研究 炎症研究
- 动脉样硬化是一种动脉样硬化.
背景情况:
- 互白素-6 (IL-6) 在慢性炎症和动脉样硬化中至关重要.
- 血清素 (5-基三胺;5-HT) 影响血管功能,但其在动脉动脉生成中的作用尚不清楚.
研究的目的:
- 研究5-HT对人类血管光滑肌细胞 (VSMCs) 中IL-6合成的影响.
主要方法:
- 通过ELISA和商业套件量化IL-6水平和mRNA积累.
- 使用凝阻滞试验评估NF-kappaB激活.
- 使用受体对抗剂 (ketanserin,sarpogrelate) 和激动剂,以及激酶抑制剂 (calphostin C,KT5720).
主要成果:
- 在VSMC中,5-HT剂量依赖增加了IL-6的产生,mRNA和NF-kappaB的激活.
- 5-HT(2A) 受体对抗性阻断了这种效应,而5-HT(2) 受体对抗性增强了它.
- 蛋白激酶C (PKC) 抑制,但不抑制PKA,抑制了5-HT诱导的IL-6产生.
结论:
- 5-HT通过5-HT2A受体和PKC依赖的通路刺激人体VSMC中的IL-6合成.
- 这些发现表明,5-HT可能会在动脉生成中促进血管炎症过程.
相关概念视频
Cofactors and Coenzymes
Enzymes require additional components for proper function. There are two such classes of molecules: cofactors and coenzymes. Cofactors are metallic ions and coenzymes are non-protein organic molecules. Both of these types of helper molecule can be tightly bound to the enzyme or bound only when the substrate binds.
Fibril-associated Collagen
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Elastin is Responsible for Tissue Elasticity
Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
Role of Skin in Vitamin D Synthesis
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Lipid-derived Compounds in the Human Body
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Exercise and Cardiovascular Response
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...


