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在左心室辅助器件支持期间的感染不会影响移植后的结果
P Sinha1, J M Chen, M Flannery
1Columbia University College of Physicians and Surgeons, Columbia Presbyterian Medical Center, New York, NY 10032, USA.
Circulation
|November 18, 2000
概括
心室辅助器件 (VAD) 支持可能会增加感染风险,但有效的管理协议意味着VAD患者与非VAD患者相比,移植存活率相似.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 移植 移植 移植 移植
背景情况:
- 在心室辅助器件 (VAD) 支持期间的感染可能会影响移植存活率.
- 与VAD相关的感染的移植后后果需要进一步调查.
研究的目的:
- 评估门诊计划,最新的VAD设备和更新的感染管理对移植后结果的影响.
- 与非VAD对照组相比,评估VAD患者的感染相关风险和生存率.
主要方法:
- 对86名VAD患者和50名匹配的非VAD对照患者的回顾性分析.
- 周周移植和移植后感染率的比较以及分别在6个月和3年的精算生存率.
- 通过临床症状和需要干预的积极培养定义的感染.
主要成果:
- 在VAD支持期间感染的高发病率没有影响移植前或移植后的死亡率或整体存活率.
- 与对照组相比,接受LVAD的人体感染率较低 (P<0.05).
- 三年生存率相似:LVAD接受者为79%,对照者为87%.
结论:
- VADs增加了移植后早期感染风险,但不会对移植能力或患者存活率产生负面影响.
- 在住院和门诊环境中,有效的感染控制策略可能会减轻不良结果.
- 现代VAD支持和管理协议有助于移植后有利的长期存活.
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