在心脏全移植血管病变中系统性炎症反应:高度敏感的C反应蛋白与渐进的光道阻塞有关
K Pethig1, B Heublein, I Kutschka
1Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany. Klaus.Pethig@t-online.de
Circulation
|November 18, 2000
概括
心脏移植接受者的渐进性心脏合移植血管病变 (CAVD) 与全身炎症有关. 高敏感性C反应蛋白 (CRP) 的升高表明CAVD进展的风险较高,有助于患者的风险评估.
科学领域:
- 心血管科学 心血管科学
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
背景情况:
- 心脏全移植血管病变 (CAVD) 是心脏移植后的加速冠状动脉综合征.
- 虽然观察到焦点炎症,但在CAVD中系统性炎症反应仍然不太了解.
研究的目的:
- 调查高灵敏C反应蛋白 (CRP) 水平与CAVD的进展之间的关联.
- 确定CRP是否可以作为心脏移植接受者系统性炎症的标志物.
主要方法:
- 研究了一组102名心脏移植 (HTX) 接受者,没有急性排斥或感染.
- 连续冠状动脉血管学评估了平均1.8年的光阻塞进展.
- 测量了高度敏感的C-反应蛋白 (CRP) 水平,并与CAVD进展相关联.
主要成果:
- 与非进展性CAVD (n=67) (1.8±1.9 mg/L) 患者相比,进展性CAVD (n=35) 患者的CRP水平显著更高 (4.1±3.3 mg/L).
- 这些发现独立于HTX的初始指示和基线CAVD严重程度.
- 在整个队列中,CRP水平在0.2至12.7毫克/升之间 (平均2.6±2.7毫克/升).
结论:
- 渐进性CAVD与全身炎症反应有关.
- 升高的CRP水平可能表明心脏移植患者中CAVD进展的风险增加.
- CRP可以作为一种有价值的指标来识别有风险的患者.
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