与非蛋白质结合的雌激素度相关的女性认知能力下降
1Department of Psychiatry, University of California, San Francisco 94121, USA. kyaffe@itsa.ucsf.edu
Lancet (London, England)
|November 21, 2000
概括
在老年女性中,较高的自由和生物可用的雌激素水平与认知能力下降的风险降低有关. 这表明内源性雌激素在维持认知功能方面起着保护作用.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 之前的研究发现,总雌激醇与认知之间没有联系.
- 血清激素水平可能不反映大脑可访问的激素度.
- 研究了与老年女性认知功能相关的自由和生物可用性激素.
研究的目的:
- 测试假设非蛋白质结合 (自由) 和松散结合 (生物可用) 性激素度与老年女性的认知功能有关.
- 为了确定特定的荷尔蒙水平是否预测老年妇女的认知衰退.
主要方法:
- 在基线和6年后使用修改的迷你精神状态检查 (mMMSE) 评估认知表现.
- 在425名女性 (≥65岁) 中,通过RIA测量非蛋白质结合和生物可用的雌激素和的血清度.
主要成果:
- 通过雌醇或丸激素三位数的初始认知分数没有差异.
- 不与蛋白质结合的雌激素的最高三位数的女性的认知障碍的几率明显较低 (调整后OR为0.3).
- 对生物可用雌激醇观察到类似的保护性关联;对没有发现关联.
结论:
- 不结合蛋白质和生物可用的雌激素的血清度较高与发展认知障碍的可能性较低有关.
- 研究结果支持这样一个假设:内源性雌激素水平的增加可能会防止老年女性的认知能力下降.
- 水平与认知障碍风险没有关联.
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