在50岁的男性中,循环免疫复合体是心肌梗塞的强大和独立的风险因素
A Mustafa1, S Nityanand, L Berglund
1Immunological Research Unit, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
50岁男性的循环免疫复合体 (CIC) 和心素自身抗体预测了未来心肌梗塞 (MI) 风险. 单独或与抗体一起增加的CICs表明风险增加,独立于其他因素.
科学领域:
- 心血管疾病研究研究
- 免疫学 免疫学 免疫学
- 预防医学 预防医学
背景情况:
- 动脉样硬化和心肌梗塞 (MI) 与循环免疫复合体 (CIC) 和针对氧化LDL和心脏脂蛋白的自身抗体有关.
- 这些生物标志物对健康人群中心脏病发作风险的预测价值以前尚不清楚.
研究的目的:
- 调查CICs和对心肌梗塞 (MI) 的自抗体对心肌素的预测能力在健康男性中.
- 为了确定这些标记能否识别未来心血管事件风险增加的个体.
主要方法:
- 一项前性嵌套病例控制研究跟踪了257名健康的50岁男性20年.
- 在基线测量CIC水平和对心血管素的自身抗体 (IgG,IgM).
- 在患有心脏病发作的男性和年龄匹配的对照者之间比较生物标志物水平.
主要成果:
- 患有心脏病发作的男性患有CIC的患病率和度高于健康对照组.
- 50岁时基线CIC度显著增加了心脏病发作风险,独立于其他风险因素.
- 升高的CIC与IgG抗体与心脏脂素相关;联合存在表明更高的风险.
结论:
- 50岁时的循环免疫复合体 (CIC) 预测了随后的心肌梗塞 (MI) 风险,直到70岁.
- 单独或与心脏脂蛋白自身抗体一起的CIC作为健康男性中心脏病发作的显著预测剂.
- 这些发现突出了早期心血管风险评估的潜在生物标志物.
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