类他类药物和痴呆症的风险
H Jick1, G L Zornberg, S S Jick
1Boston Collaborative Drug Surveillance Program, Boston University School of Medicine, Lexington, MA 02421, USA.
Lancet (London, England)
|November 23, 2000
概括
类药物显著降低了老年人痴呆症的风险. 这项研究发现,处方他类药物的人患痴呆症的风险大大降低,独立于超脂血症状态.
科学领域:
- 流行病学 流行病学
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 痴呆症影响了超过65岁的10%的人.
- 血管和脂质相关的机制与阿尔茨海默氏症和血管痴呆症有关.
- 研究降脂剂对痴呆风险的影响至关重要.
研究的目的:
- 研究HMGCoA (3-hydroxy-3-methylglutaryl-coenzyme A) 减少酶抑制剂 (他类药物) 和其他降脂剂对痴呆症的潜在影响.
- 评估50岁及以上个体的他类药物使用与痴呆症风险之间的关联.
主要方法:
- 一个嵌套的病例控制研究设计被使用来自368个英国的一般实践的数据.
- 研究人群包括50岁以上的接受降脂剂,未经治疗的高脂血症或随机选择的对照人群的个体.
- 患有痴呆症诊断的病例与根据年龄,性别,实践和索引日期的多达四个对照进行了匹配.
主要成果:
- 该研究包括284例痴呆病例和1080例对照.
- 处方他类药物的个体显示,痴呆的风险显著降低 (调整后的几率比率为0.29,p=0.002).
- 没有发现痴呆风险与未经治疗的高脂血症或非他类降脂剂之间有显著的关联.
结论:
- 在50岁及以上的个体中,他类药物处方与痴呆症风险大幅降低有关.
- 这种降低的风险独立于未治疗的高脂血症或使用非他类降脂剂.
- 该研究无法区分阿尔茨海默病和其他形式的痴呆症.
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