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在出生时体重低的9岁儿童中,内皮功能受损和心血管硬性增加
1Department of Women and Child Health, Division of Neonatology, Karolinska Hospital, Department of Clinical Science, Unit of Obstetrics and Gynecology, Huddinge Hospital, Karolinska Institutet, Stockholm, Sweden. helena.martin@kbh.ki.se
Circulation
|November 30, 2000
概括
出生时体重低 (LBW) 的儿童表现为内皮功能受损和动脉硬度增加. 这些早期的血管变化可能会增加成人心血管疾病的风险.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 血管生物学 血管生物学
- 公共卫生 公共卫生
背景情况:
- 低出生体重 (LBW) 与成人心血管疾病有关.
- 内皮功能障碍和动脉弹性降低是高血压和动脉样硬化的早期指标.
- 这项研究调查了这些血管标志物在青春期前的儿童和没有LBW.
研究的目的:
- 评估LBW儿童的内皮功能.
- 为了评估患有LBW的儿童的动脉弹性.
- 为了确定LBW是否与血管损害的早期迹象有关.
主要方法:
- 使用乙胆和酸甘评估内皮依赖和独立的血管扩张,用激光多普勒测量皮肤输液.
- 使用超声波血管壁跟踪系统测量腹腔大动脉和常见动脉弹性.
- 在22名LBW儿童和22名正常出生体重的对照者之间比较了血管标志物.
主要成果:
- 与对照组相比,患有LBW的儿童表现出明显较低的内皮依赖血管扩张 (88+/-33PU与133+/-34PU,P<0.001).
- 两组之间没有观察到大动脉或大脑动脉弹性的差异.
- 发现出生体重和动脉硬度之间存在负相关性 (r=-0.45,P<0.01).
结论:
- 有LBW病史的学生表现为内皮功能受损.
- 在LBW儿童中观察到一种增加动脉硬性的趋势.
- 这些发现表明LBW个体的早期血管妥协,可能会增加未来心血管疾病的易感性.
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