使用向激活白细胞的微泡,对炎症进行非侵入性超声波成像
1Cardiovascular Division, Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA, USA. jlindner@virginia.edu
Circulation
|November 30, 2000
概括
将氨酸氨酸 (PS) 纳入脂质微泡中,可以增强它们在炎症组织中的白细胞的附着性. 这可以通过增加保留的微泡的信号来改善炎症的超声波成像.
科学领域:
- 生物医学工程 生物医学工程
- 诊断成像 诊断成像 诊断成像
- 免疫学 免疫学 免疫学
背景情况:
- 脂质微泡用于超声波输液成像.
- 它们通过补充介导的附着在白细胞中,被保留在炎症组织中.
- 添加脂素 (PS) 可能会增强这些相互作用.
研究的目的:
- 调查脂质微泡中的酸 (PS) 是否增强白细胞的附着性,并改善炎症的超声波成像.
主要方法:
- 肠道显微镜评估了炎症小鼠肌肉中的微泡行为.
- 来自保留的微泡的超声波信号被测量在小鼠脏与或没有缺血-再输血损伤.
主要成果:
- 与标准微气泡相比,含有PS的微气泡对炎症场所的白细胞的附着性明显更大.
- 来自保留的PS微泡的超声波信号在患有缺血-再输血损伤的脏中高出2倍.
- 在超声波信号和脏炎症严重程度之间观察到强烈的相关性.
结论:
- 使用超声波成像可以实现对炎症的非侵入性评估.
- 向通过PS激活白细胞的微泡在他们的脂质外中使炎症检测成为可能.
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