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通过levonorgestrel释放子宫内系统保护子宫内膜对他莫西芬刺激的变化:一项随机对照试验
F J Gardner1, J C Konje, K R Abrams
1Department of Obstetrics and Gynaecology, University of Leicester, UK. fjegl@le.ac.uk
Lancet (London, England)
|November 30, 2000
概括
一个levonorgestrel子宫内系统可以防止因乳腺癌的他莫西芬治疗引起的子宫变化. 这种设备耐受性很好,有助于管理出血等副作用.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 塔莫西芬是乳腺癌的标准辅助疗法,但可能导致子宫出血和子宫内膜变化.
- 评估减轻他莫西芬子宫内膜的副作用的方法对于患者的健康至关重要.
- 莱沃诺格斯特勒子宫内系统 (LNG-IUS) 是一个潜在的干预措施来管理这些影响.
研究的目的:
- 评估莱沃诺格斯特勒子宫内系统在调节子宫对他莫西芬的反应中的有效性.
- 评估患者对LNG-IUS和相关查程序的耐受性.
- 为了研究LNG-IUS对子宫内膜变化和子宫肌瘤的影响,在女性服用他莫西芬.
主要方法:
- 一项随机对照试验,涉及更年期后接受辅助性他莫西芬的妇女.
- 参与者被分配到单独的子宫内膜监测或12个月的LNG-IUS插入监测.
- 使用视觉模拟秤测量耐受性;通过透视和组织学评估子宫变化.
主要成果:
- 液化天然气-IUS显示出均的果叶反应,证实了其对子宫内膜的影响.
- 在LNG-IUS组中没有观察到新的息肉,与对照组相比,观察到纤维瘤的减少.
- 虽然最初的出血增加了,但它恢复到了基线水平;这两种手术和设备都被很好地容忍.
结论:
- levonorgestrel释放的子宫内系统提供了一种保护作用,防止因他莫西芬引起的子宫变化.
- 在预防子宫内膜变化方面,LNG-IUS显示出有前途,并可能减少在服用他莫西芬的妇女中进行调查的需要.
- 需要进一步评估,以确认LNG-IUS在这种情况下的长期有效性.
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