个人胆固醇的变化对以黄油或黄油为基础的饮食的反应:一项针对家庭的研究
M A Denke1, B Adams-Huet, A T Nguyen
1Department of Internal Medicine, Center for Human Nutrition, 5323 Harry Hines Blvd, Room Y3.234, Dallas, TX 75390-9052, USA. mdenke@mednet.swmed.edu
JAMA
|December 6, 2000
概括
对降胆固醇饮食的个人反应显示出家族模式. 体重是影响个人对降低胆固醇的饮食变化做出反应的关键因素.
科学领域:
- 营养科学 营养科学
- 遗传学 是一个遗传学.
- 心血管健康 心血管健康
背景情况:
- 饮食修改有效降低了人口的LDL-C,但显示了个体的变化.
- 了解个体对饮食的反应对于个性化健康策略至关重要.
研究的目的:
- 为了调查胆固醇对饮食变化的反应的个体变化是否是家族特征.
- 确定影响个人对降胆固醇饮食反应的因素.
主要方法:
- 一个两期的交叉试验,涉及46个家庭 (92名成年人,134名儿童).
- 参与者遵循低和脂肪饮食,每人使用黄油或黄油5周.
- 在每个饮食周期的最后两周内测量平均LDL-C水平.
主要成果:
- 在成人和儿童中,玛格林的LDL-C降低率超过了黄油.
- 家庭成员解释了所有参与者的LDL-C反应变化的19%,儿童的40%.
- 身体质量指数 (BMI) 预测了反应,更重的个体显示较少的LDL-C减少.
结论:
- 对降胆固醇饮食的个人反应变化似乎是一种家族特征.
- 体重是影响胆固醇管理饮食反应的重要可改变因素.
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