慢性冠状动脉全封闭成功重通治疗后,附带功能的立即变化
G S Werner1, B M Richartz, O Gastmann
1Clinic for Internal Medicine III, Friedrich-Schiller-University Jena, Jena, Germany.
Circulation
|January 11, 2000
概括
在慢性全闭症 (TCOs) 中,冠状动脉附带循环在血管造形术后显著下降,表明对未来缺血事件的保护降低. 这项研究使用多普勒流速度计评估了TCO再通道化前后的附带流量.
科学领域:
- 心脏病学 心脏病学
- 血管生物学 血管生物学
- 干预心脏病学 干预心脏病学
背景情况:
- 冠状动脉附带体对于在慢性冠状动脉全封闭 (TCOs) 中维持心脏功能至关重要.
- 在血管造形手术前评估附带循环和其可招募的输液在再通道化后是至关重要的.
研究的目的:
- 在冠状动脉血管塑造手术前评估TCOs中的附带循环.
- 通过使用冠心内多普勒流速度计来确定可招募的附带输液.
主要方法:
- 冠心内多普勒流速计用于测量21名TCO患者在血管造形手术前的基础附带流.
- 计算了担保流量指数 (CFI),并在支架植入和重复气球膨胀后评估了可招募的担保流量.
- 血管造影和CFI重新评估是在24小时后对17名患者进行的.
主要成果:
- 基本附带流速平均为10.9厘米/秒,主要是抽缩.
- 在重新道化后,峰值附带流速下降了50%以上,至4.7厘米/秒.
- CFI从0.48大幅下降至0.21 (P<0.001),24小时没有变化. 较高的CFI与保留的心室功能相关.
结论:
- 在TCO中抵押品的流通最初提供了大量的预级流 (50%).
- 这种担保流的很大一部分在重新道化后立即丢失.
- 经过干预后,TCOs中发达的抵押功能可能无法提供对未来缺血事件的持久保护.
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