内源的Na,K联体在达尔大鼠的急性NaCl负载期间受到差异调节
O V Fedorova1, E G Lakatta, A Y Bagrov
1Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA.
Circulation
|January 11, 2000
概括
在对达尔盐敏感 (DS) 的老鼠中,急性盐负荷增加了马里诺布法根因 (MBG),这表明它补偿了分泌受损. 乌阿巴因类化合物 (OLC) 的水平暂时上升.
科学领域:
- 身体生理学 身体生理学
- 内分泌学 在内分泌学.
- 脏科学 脏科学
背景情况:
- 两种内源的数字化类因子,乌阿类化合物 (OLC) 和海洋布法 (MBG),向特定的Na(+),K(+) -ATPase异型.
- OLC的目标是α-3,而MBG的目标是α-1 Na(+),K(+) -ATPase.
研究的目的:
- 为了比较通过急性化 (NaCl) 加载对MBG和OLC的调节,在达尔盐敏感 (DS) 和耐盐 (DR) 鼠中进行了比较.
- 调查MBG和OLC在NaCl负载对尿性反应中的作用.
主要方法:
- 成年雄性DS和DR大鼠接受了腹腔内NaCl负荷.
- 测量了尿液,尿液,脏分泌和MBG和OLC的组织水平.
- 在DS,DR和Wistar大鼠中,MBG和ouabain对脏Na(+),K(+) - ATPase的抑制进行了比较.
主要成果:
- 与DR大鼠相比,DS大鼠对NaCl负载的 natriuretic反应减弱,尽管血中的含量较高.
- 无论是DS还是DR老鼠,都表现出OLC的暂时增加,但MBG的持续升高.
- 在DS大鼠中,MBG的分泌量显著高于DR大鼠在NaCl加载后.
- 来自DS大鼠的脏Na(+),K(+) -ATPase (α-1异型) 对MBG的敏感性比对ouabain更强.
结论:
- 在DS大鼠中,急性NaCl负载导致MBG水平和分泌量持续增加,与暂时的OLC增加形成鲜明对比.
- 这些发现表明,在DS大鼠中,MBG的产量升高可能会作为遗传性受损的压力自然化的一个补偿机制.
- 在DS大鼠中,MBG对α-1 Na(+),K(+) -ATPase异型的较强抑制作用支持其在调节平衡中的作用.
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