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Updated: Jul 8, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

免疫球蛋白轻链基因的体质重组部位的序列

H Sakano, K Hüppi, G Heinrich

    Nature
    |July 26, 1979
    PubMed
    概括

    研究人员对小鼠免疫球蛋白卡帕链DNA进行了测序,确定了五个连接 (J) DNA 段. 这项研究揭示了精确的重组部位,并表明体性重组期间的DNA片段切除有助于抗体多样性.

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