Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Ratio of X Chromosome to Autosomes02:45

The Ratio of X Chromosome to Autosomes

In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Mitochondrial DNA deletions parallel age-linked decline in rat sensory nerve function.

Neurobiology of aging·2001
Same author

Ruthenium-catalyzed oxidative cleavage of olefins to aldehydes.

The Journal of organic chemistry·2001
Same author

Pharmacokinetics of testosterone after percutaneous gel or buccal administration.

Fertility and sterility·2001
Same author

The leukocyte common antigen-related protein tyrosine phosphatase receptor regulates regenerative neurite outgrowth in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

Calpain activity in the rat brain after transient forebrain ischemia.

Experimental neurology·2001
Same author

Sharpening low-energy, standard-model tests via correlation coefficients in neutron beta decay.

Physical review letters·2001

相关实验视频

Updated: Jul 16, 2026

Live-cell Imaging of Sensory Organ Precursor Cells in Intact Drosophila Pupae
04:27

Live-cell Imaging of Sensory Organ Precursor Cells in Intact Drosophila Pupae

Published on: May 27, 2011

皮质瘤抑制蛋白在Drosophila神经细胞不对称分裂中的作用

T Ohshiro1, T Yagami, C Zhang

  • 1CREST, Japan Science and Technology Corporation, Sendai.

Nature
|December 16, 2000
PubMed
概括

致命巨型幼虫 (Lgl) 蛋白质对于Drosophila神经母细胞中不对称的细胞分裂至关重要,确保正确的神经命运决定. 它与Lethal大盘 (Dlg) 合作,控制关键蛋白质的局部化,创建不同的子细胞.

科学领域:

  • 发展生物学 发展生物学
  • 细胞生物学 细胞生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 细胞多样性源于不对称的细胞分裂,局部决定因素不平等地分布在子细胞中.
  • 在Drosophila神经母细胞中,不对称的分裂产生了神经母细胞和质母细胞,其中特定的蛋白质定位在顶部或底部.
  • 像普罗斯佩罗和Numb这样的神经命运决定因素基本地定位,而螺旋方向调节器Inscuteable和Bazooka则以apically定位.

研究的目的:

  • 研究瘤抑制蛋白Lethal巨型幼虫 (Lgl) 在不对称细胞分裂和神经命运决定中的作用.
  • 阐明Lgl控制基底决定因在线粒神经母细胞中的局部化的机制.
  • 了解Lgl,Lethal大盘 (Dlg) 和其他蛋白质在调节皮质蛋白向中的相互作用.

主要方法:

  • 使用Drosophila melanogaster作为一个模型生物.
  • 通过使用基因突变物,研究了线粒神经细胞中关键蛋白质 (Prospero,Numb,Inscuteable,Bazooka,Lgl,Dlg) 的局部化.
  • 研究了Lgl和肌肉蛋白之间的相互作用.

主要成果:

  • 致命巨型幼虫 (Lgl) 蛋白质对于线性神经母细胞中所有基底决定因素的不对称皮质局部化至关重要.

更多相关视频

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia
08:14

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

Published on: July 25, 2017

Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos
12:35

Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos

Published on: April 14, 2023

相关实验视频

Last Updated: Jul 16, 2026

Live-cell Imaging of Sensory Organ Precursor Cells in Intact Drosophila Pupae
04:27

Live-cell Imaging of Sensory Organ Precursor Cells in Intact Drosophila Pupae

Published on: May 27, 2011

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia
08:14

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

Published on: July 25, 2017

Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos
12:35

Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos

Published on: April 14, 2023

  • Lgl 与肌蛋白相互作用,调解这些决定因素的局部化.
  • Dlg 调节了 Lgl 的局部化,在 lgl 或 dlg 突变体中,顶端组件的局部化不受影响.
  • Lgl和Dlg在一个不同地准皮质蛋白的过程中共同起作用,从而在子细胞之间产生内在的差异.

    • 结论:

    • 致命巨型幼虫 (Lgl) 是神经命运决定不可或缺的,通过确保神经细胞分裂期间不对称的蛋白质局部化.
    • Lgl和Lethal大盘 (Dlg) 在共同的途径中作用,控制皮质蛋白向,建立细胞多样性.
    • 这种机制对于在发育过程中产生具有特定命运的独特子细胞至关重要.