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相关概念视频

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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相关实验视频

Updated: Jul 18, 2026

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

在中枢神经系统发育和可塑性方面对I类MHC的功能要求.

G S Huh1, L M Boulanger, H Du

  • 1Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. gshuh@alum.mit.edu

Science (New York, N.Y.)
|December 16, 2000
PubMed
概括

一级主要组织相容性复合体 (MHC) 分子对于神经元发育和可塑性至关重要. 这些分子的缺陷会损害神经连接的精细化,并改变哺乳动物中枢神经系统 (CNS) 的突触可塑性.

科学领域:

  • 神经科学是一个神经科学.
  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学

背景情况:

  • 第一类主要组织相容性复合体 (MHC) 分子因其在免疫反应中的作用而得到认可.
  • 这些分子还在参与活动依赖的结构和突触修饰的神经元中得到表达.
  • 在神经元发育和可塑性方面I类MHC的确切功能在很大程度上仍未定义.

研究的目的:

  • 研究I类MHC分子在发育过程中神经连接的精细化中的作用.
  • 研究I类MHC缺乏对成年哺乳动物中枢神经系统 (CNS) 突触可塑性的影响.
  • 在不同的神经元群体中探索I类MHC的表达模式.

主要方法:

  • 使用了缺乏细胞表面I类MHC或I类MHC受体CD3zeta成分的转基因小鼠.
  • 在开发过程中评估了视网膜连接到中心目标的精细化.
  • 在成年突变小鼠海马体中测量了依赖N-甲基-D-酸盐受体的长期强化 (LTP) 和长期抑郁 (LTD).
  • 在神经元马赛克中分析了特定的I类MHC信使RNA的表达模式.

主要成果:

  • 在I类MHC或CD3zeta的遗传缺陷导致在发育过程中视网膜和中央点之间的连接不完全完善.

更多相关视频

Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry
08:07

Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry

Published on: May 19, 2020

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous &beta;2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

相关实验视频

Last Updated: Jul 18, 2026

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry
08:07

Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry

Published on: May 19, 2020

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous &beta;2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

  • 成年突变小鼠表现出增强的海马体LTP和完全没有LTD.
  • 神经元的独特马赛克表达了特定的I类MHC信使RNA,表明了多样化的神经元功能.

    • 结论:

    • 第I类MHC分子在发育中的中枢神经系统中神经连接的活动依赖重塑中发挥着重要作用.
    • 这些分子在成熟的中枢神经系统中对调节突触可塑性至关重要,包括长期的强化和抑郁.
    • 这些发现突出了I类MHC在哺乳动物大脑发育和功能中的新功能.