在患有异常性静态不耐受症的患者中出现异常的气息反射反应
W B Farquhar1, J A Taylor, S E Darling
1Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Circulation
|January 11, 2000
概括
患有异常性静态不耐受症的患者表现出心脏阴道巴罗反射敏感度降低和血液体积降低,导致直立时心率过度增加. 这有助于他们的衰弱症状.
科学领域:
- 心脏病学 心脏病学
- 自主神经系统生理学 自主神经系统生理学
背景情况:
- 异常性静态不耐受症 (IOI) 导致站立时头,疲劳和恶心.
- 症状发生在血压没有显著下降的情况下,往往伴有心率加快 (心).
研究的目的:
- 为了研究IOI患者的腹反射功能,血液体积和静脉顺应.
- 了解IOI中过度姿势性心动减速症的生理基础.
主要方法:
- 通过使用修改的牛津技术评估心血管巴罗反射灵敏度.
- 利用下体负压 (LBNP) 模拟低血压并测试综合巴罗反射反应.
- 测量血液体积和静脉遵守.
主要成果:
- 与对照组相比,IOI患者表现出显著较低的心血管阴道巴罗反射灵敏度.
- 在LBNP期间,患者表现出更快的心率反应和症状增加,尽管血压稳定.
- 在患者组中观察到血液体积下降的趋势.
结论:
- 降低心管巴洛反射灵敏度和略微降低血量是IOI的特征.
- 这些因素可能会导致受影响个人的心率反应和症状过度.
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