对中度体重变化和睡眠呼吸障碍的纵向研究
P E Peppard1, T Young, M Palta
1University of Wisconsin School of Medicine, Department of Preventive Medicine, 502 N Walnut St, Madison, WI 53705, USA. ppeppard@facstaff.wisc.edu
JAMA
|December 21, 2000
概括
体重变化显著影响睡眠呼吸障碍 (SDB). 体重增加10%会增加SDB的严重程度,而体重减轻会减少,这表明体重管理是SDB控制的关键.
科学领域:
- 睡眠医学 睡眠医学
- 肥胖问题研究研究
- 公共卫生 公共卫生
背景情况:
- 体重过重与睡眠呼吸障碍 (SDB) 密切相关.
- SDB是美国人口中普遍存在的疾病.
- 关于体重变化和SDB严重性的纵向研究有限.
研究的目的:
- 为了确定体重变化和SDB严重程度之间的独立纵向关联.
- 量化体重波动对呼吸暂停-呼吸暂停指数 (AHI) 的影响.
主要方法:
- 从1989年到2000年进行了一项基于人口的前性队列研究.
- 690名威斯康星州就业居民在4年间隔两次进行评估.
- 与体重变化相对,评估了呼吸暂停-呼吸暂停指数 (AHI) 的变化和中度至重度SDB的几率.
主要成果:
- 10%的体重增加预测AHI增加32%,10%的体重减轻预测AHI下降26%.
- 体重增加10%与发展中度至重度SDB的几率增加6倍有关.
- 这些关联独立于基线体重状况.
结论:
- 促进体重控制的临床和公共卫生倡议可以有效地管理现有的SDB.
- 适度的重量管理策略可能会减少新的SDB病例的发生率.
- 体重管理是SDB综合护理的关键组成部分.
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