放射性支架延迟但不能防止支架内新极端增生症
I P Kay1, A J Wardeh, K Kozuma
1Thoraxcenter, University Hospital Rotterdam, Dijkzigt, The Netherlands.
Circulation
|January 4, 2001
概括
放射性支架最初减少了新极端增生症,但没有阻止后来的生长. 一年后的结果显示,光线明显恶化,这表明放射性支架与传统支架没有优势.
科学领域:
- 心血管医学 心血管医学
- 干预心脏病学 干预心脏病学
- 生物医学工程 生物医学工程
背景情况:
- 造后的缩症主要是由于新极度增生症.
- 放射性支架发射β粒子已经显示出在6个月后减少这种增生的潜力.
研究的目的:
- 评估 (32) P放射性支架的一年结果.
- 使用定量冠状动脉血管学和3D血管内超声波 (IVUS) 评估疗效.
主要方法:
- 使用了序列定量冠状动脉血管学和电心电图通道的体积3DIVUS.
- 40名患者最初接受了支架;22人完成了1年的随访,并进行了重复成像.
主要成果:
- 在6个月至1年之间发生了显著的光线恶化 (血管学LMD下降: -0.43mm,P=0.028).
- 在静脉支架内新极端增生症的体积显著增加 (18.16mm3到27.75mm3,P=0.001).
- 23%的患者需要目标血管再血管化;65%的患者在1年后仍然没有事件.
结论:
- 放射性支架植入延迟,但不会阻止,新极端的增殖.
- 与传统支架相比,使用这些放射性支架的1年临床结果并不有利.
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