对病原体负担和心肌梗塞或死亡风险的前性研究
1Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA.
Circulation
|January 4, 2001
概括
感染增加了心肌梗塞 (MI) 和冠状动脉疾病 (CAD) 患者死亡的风险. 较高的病原体负担,来自CMV和HAV等感染,与风险增加相关.
科学领域:
- 传染性疾病 传染性疾病
- 心血管医学 心血管医学
- 免疫学 免疫学 免疫学
背景情况:
- 以前的横截面研究将病原体负担与冠状动脉疾病 (CAD) 风险联系起来.
- 这项前性研究调查了病原体负担对心肌梗塞 (MI) 或CAD患者死亡的影响.
研究的目的:
- 为了评估病原体负担对心脏病发作或死亡风险的影响,在已确诊的CAD患者中.
- 为了确定特定的病原体或总的病原体负载是否预测不良心血管事件.
主要方法:
- 对890名CAD患者进行前性研究.
- 对各种病原体 (CMV,HAV,HSV1,HSV2,C.pneumoniae,H.pylori) 的IgG抗体和C反应蛋白 (CRP) 水平进行评估.
- 随访患者平均3年记录心脏病发作或死亡事件.
主要成果:
- 在患者中观察到较高的CMV,HAV,HSV1和HSV2抗体的患病率,这些患者后来经历了MI或死亡.
- 增加的病原体负担与心脏病发作或死亡风险的剂量反应增加显著相关.
- 对心脏病发作或死亡的调整后相对风险在CMV,HAV和HSV2感染中升高,独立于CRP水平.
结论:
- 感染在发生性心脏病发作或CAD患者死亡中起着重要作用.
- 感染带来的风险与总体病原体负担独立相关.
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