在人类中,阿尔多斯特的生产在失败的心室中被激活
Y Mizuno1, M Yoshimura, H Yasue
1Division of Cardiology, Kumamoto Aging Research Institute, Yamamuro, Kumamoto City 860-8518, Japan.
Circulation
|January 4, 2001
概括
阿尔多斯特,血管酶转化酶和BNP都是在失败的人类心脏中产生的. 它们的水平随着左心室功能障碍的严重程度而增加,表明心脏本身的局部生产.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 最近的研究表明,在动物中,额外上腺阿尔多斯特的产生.
- 人类心脏合成阿尔多素的能力在很大程度上仍未被探索.
研究的目的:
- 为了研究人类心脏中阿尔多素生产的存在和意义.
- 为了将心脏阿尔多素水平与心力衰竭的标志物相关联.
主要方法:
- 在前腔室间静脉,冠状动脉鼻腔和大动脉根中测量血中阿尔多素,BNP和ACE.
- 在患有左心室缩功能障碍 (LVSD),左心室缩功能障碍 (LVDD) 和健康对照患者中比较这些水平.
主要成果:
- 在LVSD和LVDD组中,心血管 (AIV,CS) 与大动脉相比,在心血管 (AIV,CS) 中发现了显著更高的阿尔多素水平.
- 在功能障碍组的心脏静脉与大动脉中也观察到高ACE活性和BNP水平.
- 在LVSD患者中,心脏阿尔多和BNP水平与LVEDP正相关,与LVSD射出分数负相关.
结论:
- 阿尔多,ACE和BNP的生产在失败的人类心室中被激活.
- 这种激活的程度与心力衰竭的严重程度成正比.
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