衰老和心脏缺血对睡眠期间心率变化的影响
V Crasset1, S Mezzetti, M Antoine
1Department of Cardiology/Hypertension Clinic/Cardiac Surgery, Erasme Hospital, Brussels, Belgium.
Circulation
|January 4, 2001
概括
衰老会减少深度睡眠,影响心活动的夜间增加和非REM睡眠期间高频率 (HF) 心率变化. 睡眠期间的呼吸模式会影响RR间隔中的HF振荡.
科学领域:
- 心血管生理学心血管生理学
- 睡眠医学 睡眠医学
- 自主神经系统的自主神经系统
背景情况:
- 心脏静脉调会影响心率 (RR间隔) 和心率的变化,尤其是非快速眼动 (非REM) 睡眠期间的高频 (HF) 振荡.
- 老龄化与深度睡眠减少有关,但其对睡眠相关心率调节的影响尚不清楚.
- 睡眠期间呼吸对鼻腔节点的机械影响及其对RR变异性的影响尚不清楚.
研究的目的:
- 研究衰老对睡眠架构的影响及其与心脏自主调节的关联,特别是睡眠期间的RR间隔和HF变化.
- 为了确定呼吸机制在调节RR间隔和睡眠期间HF变化的作用,独立于自主输入.
主要方法:
- 在年轻和年长的健康志愿者中进行了睡眠记录和RR间隔的光谱分析.
- 此外,在心脏神经衰竭的心脏移植接受者中,还分析了RR光谱谱,以分离呼吸机械效应.
- 睡眠阶段,包括深度睡眠 (第四阶段),被量化并与心血管参数相关.
主要成果:
- 在年轻和老年人中,过渡到非REM睡眠增加了RR间隔,但HF可变性仅在年轻人中增加.
- 与年轻人相比,老年人在非REM睡眠期间表现出更快的RR间隔和更低的HF变化.
- 衰老显著减少了深度睡眠的持续时间,这种减少与非REM睡眠期间RR间隔和HF变化率的大幅增加有关.
- 在心脏移植接受者中,非REM睡眠的开始使降低的HF可变性翻了一番,这表明机械呼吸效应.
结论:
- 与衰老相关的深度睡眠的下降减少了正常的夜间心活动的增加.
- 睡眠期间呼吸模式的变化有助于非REM睡眠期间RR间隔的高频振荡增加,主要是通过对节的机械影响.
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