在冠状动脉疾病和冠状动脉血管运动方面进行运动训练
S Gielen1, G Schuler, R Hambrecht
1Universität Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin/Kardiologie, Leipzig, Germany.
Circulation
|January 4, 2001
概括
运动训练通过增强氧化的生产和微循环来改善冠状动脉疾病患者的心脏血液流动. 这种心脏康复策略通过改善内皮功能来降低心血管风险.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 血管生物学 血管生物学
背景情况:
- 运动训练对于心脏康复至关重要,在冠状动脉疾病 (CAD) 中改善心肌输液.
- 讨论了改善 perfusion 的机制,例如动脉狭窄回归或改善附带担保.
- 内皮功能障碍与氧化物 (NO) 生产受损有关,引发心肌缺血和悖论性血管收缩.
研究的目的:
- 研究运动训练如何改善冠状动脉疾病患者心肌输液的机制.
- 阐明内皮功能和氧化通路在运动诱导的冠状动脉血流改善中的作用.
主要方法:
- 人类研究证实,训练可以减轻CAD患者的悖论性血管收缩.
- 研究表明,在训练后对乙胆的反应中,冠状动脉血流增加.
- 细胞培养和动物实验探讨了剪切应力对内皮L-氨酸运输,NO合成酶活性和超氧化物脱酶产生的影响.
主要成果:
- 运动训练被证实可以减轻CAD患者的悖论性血管收缩.
- 训练增加了冠状动脉对乙胆的血流反应.
- 机制包括增强的内皮L-氨酸运输,NO合成酶活性和细胞外超氧化物脱酶,以及对腺的微循环敏感化.
结论:
- 运动训练通过增强内皮功能和NO生物可用性来改善CAD中的心肌输液,而不仅仅是通过改变冠状动脉直径.
- 改善的内皮功能和微循环敏感化有助于减少运动引起的缺血症.
- 运动对内皮功能障碍的积极影响表明,运动在减少长期心血管疾病和死亡率方面发挥了作用.
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