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Updated: May 1, 2026

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
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Comparing the Affinity of GTPase-binding Proteins using Competition Assays

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晶体结构和Ras与其效应物酸3-酶玛酶结合的功能分析

M E Pacold1, S Suire, O Perisic

  • 1MRC Laboratory of Molecular Biology Hills Road CB2 2QH, Cambridge, United Kingdom.

Cell
|January 4, 2001
PubMed
概括

拉斯蛋白直接激活酸酸3-激酶 (PI3Kgamma),这对癌细胞生存至关重要. 结构分析揭示了这种激活必不可少的特定结合相互作用,提供了新的治疗点.

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