在感染之前,Plasmodium杂虫细胞通过细胞的迁移
M M Mota1, G Pradel, J P Vanderberg
1Department of Pathology, New York University School of Medicine, 341 East 25 Street, New York, NY 10010, USA.
Science (New York, N.Y.)
|January 6, 2001
概括
疟疾寄生虫 (Plasmodium sporozoites) 通过突破血来入侵细胞,而不是形成真空细胞. 这种独特的进入和细胞穿越对于寄生虫的发展和完成疟疾生命周期至关重要.
科学领域:
- 细胞生物学 细胞生物学
- 寄生虫学的寄生虫学
- 传染性疾病 传染性疾病
背景情况:
- 细胞内病原体通常通过真空形成进入宿主细胞.
- 疟疾寄生虫的传染阶段 - - 疟原虫杂虫 (Plasmodium sporozoites) 需要有效地进入细胞以感染.
- 了解Plasmodium sporozoite入侵机制是制定疟疾控制策略的关键.
研究的目的:
- 为了研究Plasmodium sporozoites的替代细胞进入机制.
- 为了阐明除了最初的宿主细胞相互作用之外的杂虫虫入侵过程.
- 确定细胞穿越在疟疾寄生虫生命周期中的作用.
主要方法:
- 现场成像显微镜观察与宿主细胞的Plasmodium sporozoite相互作用.
- 宿主细胞血完整性的分析在杂虫细胞进入过程中.
- 追踪宿主组织内的杂虫细胞运动.
主要成果:
- 菌体虫突破了宿主细胞的血膜,然后迅速修复.
- 这种进入机制绕过了传统的真空球形成,允许寄生虫立即释放到细胞质中.
- 草原虫通过多个宿主细胞迁移,然后通过寄生虫的真空细胞在肝细胞中感染.
结论:
- 菌体使用一种独特的非真空侵入途径,涉及到膜破裂和修复.
- 细胞体通过多个宿主细胞的穿越对于Plasmodium sporozoite的发育和传染性至关重要.
- 这种迁徙行为对于完成疟疾寄生虫在哺乳动物宿主中的生命周期至关重要.
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