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相关概念视频

Blind Procedures02:07

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...

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Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
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在最近心肌梗塞和左心室功能障碍患者中多菲提利德的作用:一项随机试验.

L Køber1, P E Bloch Thomsen, M Møller

  • 1Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark. lk@heart.dk

Lancet (London, England)
|January 6, 2001
PubMed
概括

在心肌梗塞后的左心室功能障碍患者中,多菲提利德并没有降低死亡率. 然而,它在高风险人群中有效治疗心房动或动.

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科学领域:

  • 心脏病学 心脏病学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 心肌梗塞 (MI) 后的心律失常对死亡率有显著的贡献.
  • 以前的抗心律失常药物试验已经显示出有限的疗效.
  • 多菲提利德是一种新型的III类抗不律性药物,在心脏病后的左心室功能障碍患者中进行了评估.

研究的目的:

  • 为了研究多菲提利德对所有原因死亡率和发病率的影响,在心脏病发作后患有左心室功能障碍的患者中.
  • 评估多菲提利德在降低心脏病和心律失常死亡率方面的疗效.

主要方法:

  • 一个随机的,双盲的,安慰剂对照试验,涉及1510名患有严重左心室功能障碍的患者 (射出分数≤0.35) 在37个丹麦冠状动脉护理单位.
  • 患者被分配给接受多菲提利德 (n=749) 或安慰剂 (n=761).
  • 主要终点是全因死亡率;次要终点包括心脏和心律失常死亡率.

主要成果:

  • 在多菲提利德和安慰剂组之间,所有原因死亡率 (31%对32%),心脏病死亡率 (26%对28%) 或整体心律失常死亡率 (17%对18%) 没有显著差异.
  • 多菲提利德在患有心房动或动的患者中恢复鼻节律方面表现出显著的疗效 (25/59对7/56;p=0.002).
  • 发生了7例torsade de pointes心室低心率病例,所有病例都发生在多菲提利德组中.

结论:

  • 多菲提利德治疗没有影响所有原因的死亡率,心脏死亡率或心律不整的死亡,这些患者患有严重的左心室功能障碍后MI.
  • 在这种特定的患者群体中,多菲提利德被证明有效治疗心房动或动.
  • 这项研究强调了多菲提利德在某些心律失常症的节律控制中的潜在作用,尽管在这个高风险组中缺乏死亡率益处.