甲状腺菌的血清型和宫状细胞癌的发展风险
T Anttila1, P Saikku, P Koskela
1Department of Obstetrics and Gynecology, University of Helsinki, Haartmaninkatu 2, 00290 Helsinki, Finland.
JAMA
|January 10, 2001
概括
克拉米迪亚形虫血清型G显著增加了宫状细胞癌的风险. 多个血清型暴露进一步提高了这种风险,加强了克拉米迪亚虫感染和子宫癌之间的联系.
科学领域:
- 妇科瘤学 妇科瘤学
- 传染病流行病学 传染病流行病学
- 癌症研究 癌症研究
背景情况:
- 人类乳头瘤病毒 (HPV) 是已知的宫癌的原因之一.
- 甲状腺炎 (C. trachomatis) 感染也与子宫状细胞癌 (SCC) 风险的增加有关,但血清型特异性尚不清楚.
研究的目的:
- 调查特定的C. trachomatis血清型与宫SCC的发展之间的关联.
- 为了确定宫SCC的风险是否因C. trachomatis血清型而异.
主要方法:
- 一项纵向的,嵌套的病例控制研究使用来自芬兰,挪威和瑞典的53万名妇女的血清库样本进行.
- 这项研究包括128名患有侵袭性宫SCC的妇女和每例3名匹配的对照,数据与国家癌症登记处相关联.
- 风险由IgG抗体对10C. trachomatis血清型进行评估,并根据HPV类型16,18,33和血清中胆固醇水平进行调整.
主要成果:
- 在C. trachomatis血清型G中,与SCC的关联最强 (调整后OR,6.6).
- 血清型I (OR,3.8) 和D (OR,2.7) 也与增加SCC风险有关.
- 对多种C. trachomatis血清型的暴露显著增加了SCC的调整后的几率比率 (P<.001为趋势).
结论:
- C. trachomatis G 血清型最强烈地与随后的宫SCC 发展有关.
- 暴露于不同C. trachomatis血清型的增加增加了宫SCC的风险.
- 这些发现加强了过去的C. trachomatis感染和宫SCC之间的关联.
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