从急性冠状动脉综合征患者的冠状动脉样本中增加了血管氨酸转化酶活性
1Division of Cardiology, Osaka Rosai Hospital, Sakai, Osaka, Japan. hoshidas@orh.go.jp
Circulation
|February 7, 2001
概括
血管血管酶转化酶 (ACE) 活性在急性冠状动脉综合征罪祸首病变中升高,这表明它在活跃冠状动脉病变的发展中发挥了作用. 这与稳定的缺血性心脏病和静脉复缩形成鲜明对比,在这些情况下,ACE活性没有显著增加.
科学领域:
- 心血管医学 心血管医学
- 生物化学 生物化学
- 干预心脏病学 干预心脏病学
背景情况:
- ангиотензин转化酶 (ACE) 抑制剂对于二次预防缺血性心脏病至关重要.
- 然而,ACE抑制剂在冠状动脉手术后不能有效地预防复原.
- 在罪祸首冠状动脉病变中的血管ACE活性仍未得到量化.
研究的目的:
- 量化在冠状动脉病变中的血管ACE活性.
- 为了研究ACE活性和急性冠状动脉综合征 (ACS) 与稳定性缺血性心脏病 (SIHD) 具有或没有复原症之间的关系.
主要方法:
- 通过定向冠状动脉切除术获得了血管组织.
- 在患有ACS (n=17) 和SIHD (n=36) 的患者中测量了ACE活性.
- 患有SIHD的患者被分为带有和没有缩症的群体,包括内置缩症和与缩症无关的缩症.
主要成果:
- 在ACS患者的罪祸首病变中,ACE活性显著增加 (0.87±0.12nmol/min/mg蛋白;P<0.01).
- 在SIHD患者中没有观察到ACE活性的显著差异,与没有恢复的患者 (0.19±0.05) 相比,与没有恢复的患者 (0.20±0.05) 相比.
- 血清ACE活性在患者组之间没有显著差异.
结论:
- 与急性冠状动脉综合征相关的罪祸首病变中存在增强的血管ACE活性.
- 这一发现表明,增加的ACE活性有助于活性冠状动脉病变的发病.
- 血管ACE活性可能是ACS.新治疗策略的目标.
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