在先天性心脏病中大动脉壁的结构异常:光和电子显微镜分析分析
K Niwa1, J K Perloff, S M Bhuta
1Ahmanson/UCLA Adult Congenital Heart Disease Center, University of California, Los Angeles, USA.
Circulation
|February 7, 2001
概括
大动脉中部异常常见于先天性心脏病 (CHD),可能导致危险的扩张和破裂. 需要进一步的研究来了解它们的原因和影响.
科学领域:
- 心血管病理学心血管病理学
- 遗传性心脏病研究 遗传性心脏病研究
- 动脉壁生物学 动脉壁生物学
背景情况:
- 在先天性心脏病 (CHD) 中的大动脉容易扩张,动脉瘤形成和破裂.
- 这些动脉壁的底层中间异常仍然不太清楚.
- 这项研究调查了所有年龄段患者的18种心血管疾病中介性异常.
研究的目的:
- 在患有先天性心脏病的患者中,以表征上升性大动脉,偏性大动脉,大动脉干和肺干的中间异常.
- 建立基于光和电子显微镜的介质异常分级系统.
- 探索这些异常与动脉扩张和破裂等临床结果之间的潜在联系.
主要方法:
- 对102名患有各种形式心血管疾病的患者的手术内活检和尸体解剖样本的分析.
- 使用光显微镜 (LM) 和电子显微镜 (EM) 检查样本.
- 与对照组进行比较,包括马方综合征患者和患有主动脉病的人.
主要成果:
- 在广泛的心血管疾病患者中,上升性大动脉,偏性大动脉,大动脉干和肺干中普遍存在中部异常.
- 基于LM和EM发现开发了一个分级系统,以量化中间异常的严重程度.
- 该研究确定了不同类型心血管疾病中受这些异常影响的特定动脉段.
结论:
- 中间异常是各种形式的先天性心脏病的共同特征.
- 这些异常可能使受影响的动脉易于扩张,动脉瘤形成和破裂.
- 关于这些异常的固有性与获得性,心血管疾病的作用以及潜在的遗传因素,仍然存在关键问题.
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